- 专利标题： COMPOSITIONS AND METHODS OF TREATMENT WITH PRODRUGS OF TIZOXANIDE, AN ANALOGUE OR SALT THEREOF
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申请号： US16153070申请日： 2018-10-05
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公开(公告)号： US20190040026A1公开(公告)日： 2019-02-07
- 发明人: Jean-Francois Rossignol , Andrew Stachulski
- 申请人： Romark Laboratories, L.C.
- 申请人地址： US FL Tampa
- 专利权人： Romark Laboratories, L.C.
- 当前专利权人： Romark Laboratories, L.C.
- 当前专利权人地址： US FL Tampa
- 主分类号： C07D277/58
- IPC分类号： C07D277/58 ; A61P35/00 ; A61K31/555 ; A61P31/12 ; A61K45/06 ; C07D277/46 ; A61K31/138 ; A61K9/48 ; A61K31/506 ; A61K9/20 ; A61K31/426 ; A61P31/04 ; A61K31/704 ; A61K31/7068
摘要：
Prodrugs of tizoxanide, an analogue or salt thereof are disclosed. The prodrugs have an ester moiety comprising an amino acid moiety, and increase the bioavailability of the tizoxanide, an analogue or salt thereof. Compositions and methods of treating an intracellular protozoan infection, a viral infection or a cancer are also disclosed.
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