- 专利标题: MOLECULAR MARKER FOR CANCER STEM CELL
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申请号: US16110001申请日: 2018-08-23
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公开(公告)号: US20190054141A1公开(公告)日: 2019-02-21
- 发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
- 申请人: Sapporo Medical University , Sumitomo Dainippon Pharma Co., Ltd.
- 申请人地址: JP Sapporo-shi JP Osaka
- 专利权人: Sapporo Medical University,Sumitomo Dainippon Pharma Co., Ltd.
- 当前专利权人: Sapporo Medical University,Sumitomo Dainippon Pharma Co., Ltd.
- 当前专利权人地址: JP Sapporo-shi JP Osaka
- 优先权: JP2008-275539 20081027; JP2009-068656 20090319
- 主分类号: A61K38/17
- IPC分类号: A61K38/17 ; C12N15/113 ; C12N5/0783 ; C07K7/06 ; G01N33/574 ; G01N33/50 ; C12Q1/6886
摘要:
A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
公开/授权文献
- US11382952B2 Molecular marker for cancer stem cell 公开/授权日:2022-07-12