Described herein are various antimicrobial articles that have reduced discoloration after the formation of a silver-containing region in a substrate. The improved antimicrobial articles described herein generally include a substrate that comprises a compressive stress layer and a silver-containing region that each extend inward from a surface of the substrate to a specific depth, and has a uniform silver concentration profile across the surface of the substrate, such that the article exhibits little-to-no discoloration. Methods of making and using the articles are also described.