A method for segmentation of an organ structure of an examination object in medical image data, a processing unit, a medical imaging device and a computer program product are disclosed. In an embodiment, the method, for segmentation of an organ structure of an examination object in medical image data, includes acquiring genetic data of an examination object, characterizing a morphological variation of an organ structure; acquiring medical image data from the examination object; segmenting the organ structure in the medical image data using a segmentation algorithm, wherein the genetic data is entered into the segmentation algorithm in addition to the medical image data, as input parameters, and wherein the segmentation algorithm takes account of morphological variation of the organ structure during the segmenting of the organ structure, to proce a segmented organ structure; and provisioning the segmented organ structure.