A system for detecting clinical deterioration in a patient having a health condition during one or more post-discharge patient follow-up periods is provided. The system includes a computer system that has one or more physical processors programmed with computer program instructions which, when executed cause the computer system to: determine a clinical deterioration risk detection model for each of the post-discharge patient follow-up periods, and determine a clinical deterioration risk detection value for the patient in the post-discharge patient follow-up period using the corresponding clinical deterioration risk detection model. The clinical deterioration risk detection model is a function of health information of the patient in the corresponding post-discharge patient follow-up period. The clinical deterioration risk detection value is configured to predict the likelihood of the clinical deterioration in the patient in the post-discharge patient follow-up period.