A dynamically adaptive neural network processing system includes memory to store instructions representing a neural network in contiguous blocks, hardware acceleration (HA) circuitry to execute the neural network, direct memory access (DMA) circuitry to transfer the instructions from the contiguous blocks of the memory to the HA circuitry, and a central processing unit (CPU) to dynamically modify a linked list representing the neural network during execution of the neural network by the HA circuitry to perform machine learning, and to generate the instructions in the contiguous blocks of the memory based on the linked list.