A method for providing an orally dissolvable composition of menthol, 1-arginine and one or more cannabinoids for quickly and reliably providing enhanced pharmacokinetic bioavailability of the cannabinoids to a mammalian subject. The orally dissolvable composition is preferably in the form of a thin orally dissolving mucoadhesive strip or film that is placed in the buccal cavity or under the tongue of a user. The menthol and 1-arginine function as permeation enhancers and local vasodilators, providing improved oral transmucosal absorption of the cannabinoids.