Articles of footwear may include an upper formed from one or more upper parts, wherein at least one upper part defines an ankle-containing portion of the upper and at least one upper part (the same upper part or a different upper part) defines an instep-containing portion of the upper. The foot-insertion opening of the upper (which may include a closure system) may extend: (i) from a first side of an ankle-containing portion of the upper, (ii) around a rear heel or ankle area of the upper, (iii) along a second side of the ankle-containing portion of the upper, and (iv) to an instep-containing portion of the upper. One or more additional straps (e.g., an ankle strap, one or more interior bootie straps, etc.), fasteners, and/or locks may be provided to engage the upper/footwear with the wearer's foot.