Invention Application
- Patent Title: Compositions And Methods For Manipulation Of Adipocyte Energy Consumption Regulatory Pathway
-
Application No.: US15539621Application Date: 2015-12-23
-
Publication No.: US20190136232A1Publication Date: 2019-05-09
- Inventor: Manolis Kellis , Melina Christine Claussnitzer , Jan Korbel
- Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EUROPEAN MOLECULAR BIOLOGY LABORATORY
- International Application: PCT/US15/00311 WO 20151223
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/90
Abstract:
Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.
Public/Granted literature
- US10774326B2 Compositions and methods for manipulation of adipocyte energy consumption regulatory pathway Public/Granted day:2020-09-15
Information query
IPC分类:
