An electrostatic atomization ultrasonic aided low-damage and controllable biologic bone grinding process and device, which solve the problem of debris blockage and have good cooling effect and high operation efficiency. The device includes: a spindle, arranged rotatably; a water-catching grinding tool for grinding a biologic bone, the spindle being connected with the tool through an ultrasonic vibration mechanism, the tool achieving longitudinal and rotary motions under the drive of the spindle and mechanism; a cooling and film forming mechanism on one side of the tool and connected with an ultrasonic generator in the mechanism, a nozzle connected with a medical nano liquid storage cup arranged at the bottom, compressed gas capable of being introduced into the nozzle to perform pneumatic-ultrasonic atomization on a medical nanofluid, the nanofluid being flushed into a grinding zone in droplets for effective cooling and lubrication; and an endoscope on the other side of the tool.