- 专利标题: NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
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申请号: US16269779申请日: 2019-02-07
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公开(公告)号: US20190169226A1公开(公告)日: 2019-06-06
- 发明人: Boyd L. Harrison , Gabriel Martinez Botella , Albert Jean Robichaud , Francesco G. Salituro
- 申请人: Sage Therapeutics, Inc.
- 主分类号: C07J41/00
- IPC分类号: C07J41/00 ; C07J5/00 ; C07J7/00 ; C07J17/00
摘要:
Described herein are steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2a, R2b, R3, R4, R5a, R5b, R6, and Z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
公开/授权文献
- US10745436B2 Neuroactive steroids, compositions, and uses thereof 公开/授权日:2020-08-18