- 专利标题： PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF
-
申请号： US16274352申请日： 2019-02-13
-
公开(公告)号： US20190177309A1公开(公告)日： 2019-06-13
- 发明人: Sanjay Jagdish DESAI , Jayprakash Ajitsingh PARIHAR , Alpesh Pravinchandra SHAH
- 申请人： CADILA HEALTHCARE LIMITED
- 申请人地址： IN Ahmedabad
- 专利权人： CADILA HEALTHCARE LIMITED
- 当前专利权人： CADILA HEALTHCARE LIMITED
- 当前专利权人地址： IN Ahmedabad
- 优先权： IN201621015388 20160503; IN201621018551 20160530; IN201721009474 20170318
- 主分类号： C07D409/14
- IPC分类号： C07D409/14 ; C07D333/54 ; C07D247/02 ; A61K31/496 ; C07D401/12 ; A61K9/14
摘要：
The present invention relates to Brexpiprazole having a purity of about 99.5% or more by area percentage of HPLC, having total impurities not more than 0.5% relative to brexpiprazole as measured by area percentage of HPLC, and having less than 0.1% 1-(benzo[b]thiophen-4-yl)piperazine or a salt thereof relative to brexpiprazole by area percentage of HPLC. The present invention also provides a composition comprising brexpiprazole having 1-(benzo[b]thiophen-4-yl)-piperazine or a salt thereof in an amount less than about 0.1% relative to brexpiprazole by area percentage of HPLC and process for the preparation of brexpiprazole.
公开/授权文献
信息查询
