A surgical stapler for stapling the tissue of a patient is disclosed. The surgical stapler comprises a handle, a shaft extending from the handle, and an end effector extending from the shaft, wherein the end effector comprises a plurality of staples and an anvil configured to deform the staples. The surgical stapler further comprises a firing mechanism configured to deploy the staples, a sensor configured to detect a target, a controller configured to calculate the firing path based on the target, and a motorized drive system configured to move the end effector toward the target along the firing path.