- 专利标题： LONG-ACTING PCSK9-SPECIFIC BINDING PROTEIN AND APPLICATION THEREOF
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申请号： US16308811申请日： 2017-06-08
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公开(公告)号： US20190194356A1公开(公告)日： 2019-06-27
- 发明人: Shaoxiong Wang
- 申请人： CHANGZHOU BOJIA BIOTECHNOLOGY CO., LTD
- 优先权： CN201610405036.7 20160608
- 国际申请： PCT/CN2017/087536 WO 20170608
- 主分类号： C07K16/40
- IPC分类号： C07K16/40 ; A61P3/06 ; G01N33/58 ; C12N15/62
摘要：
Provided is a long-acting PCSK9-specific binding protein and application thereof. Provided is an MV072 protein with unique complementarity-determining regions, i.e., a binding protein specifically binding to proprotein convertase subtilisin kexin type 9 (PCSK9). The protein can specifically bind to PCSK9, effectively inhibit the function of PCSK9 and reduce plasma LDL cholesterol level. Further provided is an application of the binding protein in treating diseases related to or influenced by the function of PCSK9.