- 专利标题: MNK INHIBITORS AND METHODS RELATED THERETO
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申请号: US16178678申请日: 2018-11-02
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公开(公告)号: US20190209560A1公开(公告)日: 2019-07-11
- 发明人: Siegfried H. Reich , Paul A. Sprengeler , Stephen E. Webber , Alan X. Xiang , Justin T. Ernst
- 申请人: eFFECTOR Therapeutics, Inc.
- 专利权人: eFFECTOR Therapeutics, Inc.
- 当前专利权人: eFFECTOR Therapeutics, Inc.
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; A61K31/551 ; A61K31/52 ; A61K31/519 ; C07D519/00 ; C07D495/20 ; C07D471/04 ; C07D471/20 ; C07D471/10 ; C07D487/04 ; C07D473/34 ; C07D491/20
摘要:
The present invention relates to compounds according to Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4a, R4b, R5, R6, R7, R8, W1, W2, Y and n are as defined herein. Also described are pharmaceutically acceptable compositions of Formula I compounds as well as methods for utilizing the compounds of Formula I and the pharmaceutically acceptable compositions of Formula I compounds as inhibitors of Mnk as well as therapeutics for the treatment of diseases such as cancer.
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