The present disclosure provides a method of driving a display panel, a driving circuit, a display panel, and a display device. The method comprises: when a scene change is detected, determining whether a time when the scene change occurs is in a process of scanning a frame of display screen of a first scene; and if so, controlling a gate driving circuit to re-scan respective gate lines on the display panel sequentially, and controlling a source driving circuit to input display signals of a second scene to respective pixels connected to the respective gate lines, the second scene being different from the first scene.