发明申请
- 专利标题: PROINSULIN DERIVATIVES
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申请号: US16330154申请日: 2017-09-05
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公开(公告)号: US20190263881A1公开(公告)日: 2019-08-29
- 发明人: Dimitrios GATOS , Alexandra ANASTASIOU , Kleomenis Barlos
- 申请人: CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.
- 优先权: GR20160100458 20160906
- 国际申请: PCT/IB2017/055336 WO 20170905
- 主分类号: C07K14/62
- IPC分类号: C07K14/62 ; A61P3/10
摘要:
A first aspect of the invention relates to a polypeptide compound of formula (I): A-C-B (I) wherein: A is the A chain of insulin or a functional derivative or variant thereof; B is the B chain of insulin or a functional derivative or variant thereof; C is a peptide of the formula: (X1)p—(X2)n—(X3)q wherein: each X1 and X3 is independently a basic amino acid; each X2 is independently a natural or unnatural amino acid; p is 1 or 2; q is 0, 1 or 2; n is 0, 1, 2 or 3. Further aspects of the invention relate to pharmaceutical compositions comprising said polypeptide compound, and therapeutic uses thereof. Another aspect relates to the use of said polypeptide compounds in the preparation of insulin and derivatives thereof.
公开/授权文献
- US11230585B2 Proinsulin derivatives 公开/授权日:2022-01-25