发明申请
- 专利标题： INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
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申请号： US16461880申请日： 2017-11-13
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公开(公告)号： US20190276443A1公开(公告)日： 2019-09-12
- 发明人: Dong-Ming Shen , Thomas H. Graham , Jinlong Jiang , Fa-Xiang Ding , Clare Tudge
- 申请人： Dong-Ming SHEN , Thomas H. GRAHAM , Jinlong JIANG , Fa-Xiang DING , Clare TUDGE , Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2017/061226 WO 20171113
- 主分类号： C07D409/12
- IPC分类号： C07D409/12 ; A61P1/16 ; C07D209/08 ; C07D401/12 ; C07D413/12 ; C07D409/14
摘要：
The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, nonalcoholic steatohepatitis (NASH), cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.