- 专利标题： SELECTIVE INHIBITORS OF GENTOTOXIC STERESS-INDUCED IKK/NF-KB PATHWAYS
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申请号： US16349580申请日： 2017-11-14
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公开(公告)号： US20190276452A1公开(公告)日： 2019-09-12
- 发明人: Claus Scheidereit , Michael Willenbrock , Peter Lindemann , Silke Radetzki , Jens-Peter Von Kries , Marc Nazare
- 申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft , Forschungsverbund Berlin e.V.
- 优先权： EP16198731.8 20161114
- 国际申请： PCT/EP2017/079181 WO 20171114
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D471/14 ; C07D209/56 ; C07D487/04 ; C07D221/06 ; A61P35/00
摘要：
A method is for treatment of a disease associated with genotoxic stress-induced inhibitor of nuclear factor-κB kinase/nuclear factor kappa-light chain enhancer of activated B cells (IKK/NF-κB) signaling. The method can include administering a compound to a subject having a cancer exhibiting genotoxic stress induced IKK/NF-κB activation.
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