The present disclosure provides systems and methods that leverage machine-learned models (e.g., neural networks) to provide video frame synthesis. In particular, the systems and methods of the present disclosure can include or otherwise leverage a machine-learned video frame synthesis model to allow for video frames to be synthesized from videos. In one particular example, the video frame synthesis model can include a convolutional neural network having a voxel flow layer and provides one or more synthesized video frames as part of slow-motion video.