The present application is directed to Large Enclosed Secure Greenhouse Structure Atrium/Hybrid Greenhouse Buildings that have the appearance of a new modern industrial building that will provide a complete agricultural growing facility with an office, maintenance and dry storage spaces. The roof and walls of the greenhouse area have a continuous sealed chamber through transparent open web joists and girders, with controlled sunlight transmission along with heat and cold circulation. More particularly, the Atrium/Hybrid Greenhouse Building provided is constructed using a number of joist and girder systems configured to support transparent reinforced roof, wall and ceiling panels, assembled in a way that provides maximum daylight transmission and significant insulating properties, enabling the Atrium/Hybrid Greenhouse Building to be an effective and economical grow-house in harsh environments and in areas with snowfall or widely varying temperature ranges. The air in the building will be filtered through a system capable of filtering out a variety of particle matter including pesticides and herbicides with clean rooms between separate growing areas and exit areas. The Atrium/Hybrid Greenhouse Building provided is constructed using a number of joist and girder systems configured to support transparent reinforced roof, wall and ceiling panels.