Systems and methods for dynamically modifying coherence domains are discussed herein. In various embodiments, a hardware controller may be provided that is configured to automatically recognize application behavior and dynamically reconfigure coherence domains in hardware and software to tradeoff performance for reliability and scalability. Modifying the coherence domains may comprise repartitioning the system based on cache coherence independently of one or more software layers of the system. Memory-driven algorithms may be invoked to determine one or more dynamic coherence domain operations to implement. In some embodiments, declarative policy statements may be received from a user via one or more interfaces associated with the controller. The controller may be configured to dynamically adjust cache coherence policy based on the declarative policy statements received from the user.