A display substrate and a display device. The display substrate includes a signal line, an electro-static lead-out line, and an electro-static discharge unit including a first thin film transistor, a third thin film transistor and a fourth thin film transistor; a drain electrode and a gate electrode of the first thin film transistor are connected to the signal line; a source electrode of the first thin film transistor, a gate electrode of the third thin film transistor and a gate electrode of the fourth thin film transistor are connected to a first node; a drain electrode of the third thin film transistor and a drain electrode of the fourth thin film transistor are connected to the signal line; a source electrode of the third thin film transistor and a source electrode of the fourth thin film transistor are connected to the electro-static lead-out line.