The present invention involves methods of stimulating tissue using one or more series of electrodes to apply energy through a combination of electrodes to stimulate various regions within an area of interest. Such an approach can triangulate areas where stimulation and/or treatment is needed for deep brain stimulation (DBS). In addition, the triangulation system and methods described herein can be applied to any portion of a body where stimulation of a particular area is required while using the vascular network to access tissue surrounding that particular area so that a combination of electrodes can be used to identify the region of interest that requires stimulation.