Implementations detailed herein include description of a computer-implemented method. In an implementation, the method at least includes attaching a first set of one or more accelerator slots of an accelerator appliance to an application instance of a multi-tenant provider network according to an application instance configuration, the application instance configuration to define per accelerator slot capabilities to be used by an application of the application instance, wherein the multi-tenant provider network comprises a plurality of computing devices configured to implement a plurality of virtual compute instances, and wherein the first set of one or more accelerator slots is implemented using physical accelerator resources accessible to the application instance; while performing inference using the loaded machine learning model of the application using the first set of one or more accelerator slots on the attached accelerator appliance, managing resources of the accelerator appliance using an accelerator appliance manager of the accelerator appliance.