Invention Application
- Patent Title: SYSTEMS AND METHODS FOR VISUALIZATION OF SINGLE-CELL RESOLUTION CHARACTERISTICS
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Application No.: US16454485Application Date: 2019-06-27
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Publication No.: US20200005902A1Publication Date: 2020-01-02
- Inventor: Jeffrey Mellen , Kevin J. Wu , Vijay Kumar Sreenivasa Gopalan , Nicolaus Lance Hepler , Jasper Staab
- Applicant: 10X Genomics, Inc.
- Main IPC: G16B45/00
- IPC: G16B45/00 ; G16B20/40 ; C12Q1/68

Abstract:
A dataset is obtained comprising data blocks, each representing a different characteristic, for a plurality of cells across a plurality of bins, each bin representing a different portion of a reference sequence. Cells are clustered on one such characteristic across the bins thereby forming a tree that includes root, intermediate, and terminal nodes, where the cells are terminal nodes and intermediate nodes have daughter nodes, themselves being intermediate nodes or a cell. A subset of the tree is displayed that includes the root and leaves, each leaf representing an intermediate node or a cell. A heat map of the characteristic is also displayed, the map including a segment for each leaf, across the bins. When a segment represents an intermediate node, it is an average of the characteristic across daughters of the node. Graphs of characteristics for the root across the bins are also displayed.
Public/Granted literature
- US11574706B2 Systems and methods for visualization of single-cell resolution characteristics Public/Granted day:2023-02-07
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