Methods and systems for optimizing performance of a cyber-physical system include training a machine learning model, according to sensor data from the cyber-physical system, to generate one or more parameters for controllable sensors in the cyber-physical system that optimize a performance indicator. New sensor data is collected from the cyber-physical system. One or more parameters for the controllable sensors are generated using the trained machine learning module and the new sensor data. The one or more parameters are applied to the controllable sensors to optimize the performance of the cyber-physical system.