An optical image sensing module includes a base, an optical body, at least one light emitting component, and a sensing unit. The base has a light shielding portion and a bottom portion. The light shielding portion protrudes from the bottom portion. The light shielding portion has a first opening. The bottom portion has a second opening to correspond to the light shielding portion and a third opening adjacent to the second opening. The optical body is located on the base and has a lens portion and a light guiding portion. The lens portion is connected to the light guiding portion, and is adjacent to the first opening. The light emitting component is disposed within the third opening. The sensing unit is disposed in the second opening.