A sterilizing and soaking device for leather manufacturing includes a disinfecting machine (11), a soaking cavity (12) is formed in the disinfecting machine (11), the upper side of the soaking cavity (12) is communicated with an accommodating cavity (13) which penetrates left and right and is upward in opening, a rotating device (101) is arranged in the soaking cavity (12). The cow leather can be better contacted with the disinfectant, the cow leather can be automatically driven to rotate, the disinfection efficiency is increased, the water flow generated by rotation can be used for stirring the disinfectant, so that the disinfectant is uniformly mixed, and the disinfection effect is enhanced.