An ultrasound imaging system includes a beamformer configured to generate 2-D images offset from each other based on sweeping motion of a transducer array during a 3-D ultrasound imaging procedure producing volumetric data. The ultrasound imaging system further includes a 2-D mask processor configured to generate a 2-D mask image for each of the 2-D images. Each of the 2-D mask images includes a contour of a predetermined structure of interest in the volumetric data. The ultrasound imaging system further includes a 3-D mask processor configured to segment the structure from the 3-D image with the 2-D mask images, generating a 3-D segmentation.