- 专利标题: QUADRICISTRONIC SYSTEM COMPRISING A HOMING RECEPTOR AND CHIMERIC ANTIGEN RECEPTOR FOR STABLE GENETIC MODIFICATION OF CELLULAR IMMUNOTHERAPIES
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申请号: US16708082申请日: 2019-12-09
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公开(公告)号: US20200093863A1公开(公告)日: 2020-03-26
- 发明人: Hans G. Klingemann , Laurent H. Boissel , John H. Lee , Nathan T. Schumer
- 申请人: NANTKWEST, INC.
- 主分类号: A61K35/17
- IPC分类号: A61K35/17 ; C07K14/725 ; C07K14/705 ; A61P35/02 ; C07K14/55 ; C12N15/85 ; A61K9/00 ; C07K14/54 ; C07K14/82 ; C12N15/62
摘要:
Provided herein are modified NK-92® cells comprising one or more nucleic acids encoding i) a homing receptor, ii) Antigen Binding Protein (ABP) or Chimeric Antigen Receptor (CAR) that specifically binds to a target antigen, iii) an Fc Receptor such as CD16 or CD16-158V, and/or iv) a cytokine, wherein the nucleic acid sequence is operably linked to a promoter. Further provided herein are modified NK-92® cells comprising one or more nucleic acids encoding i) IL-12 and/or TGF-beta trap, ii) an Antigen Binding Protein (ABP) or Chimeric Antigen Receptor (CAR) that specifically binds to a target antigen, iii) an Fc Receptor such as CD16 or CD16-158V, and/or iv) a cytokine, wherein the nucleic acid sequence is operably linked to a promoter. Also provided are compositions and kits comprising the modified NK-92® cells, as well as methods of treating cancer using the modified cells.