Starting execution of a mobile application on a mobile device includes creating a process that is used by the operating system of the mobile device to execute the mobile application on the mobile device. An initialization method is invoked by the mobile application that i) instantiates a replacement instrumentation object, and ii) assigns the replacement instrumentation object to the process used by the operating system to execute the mobile application on the mobile device. The replacement instrumentation object processes calls from the operating system to the mobile application and redirects at least one call made by the operating system to the mobile application to at least one call to mobile application management logic executing on the mobile device.