Invention Application
- Patent Title: IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION
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Application No.: US16538917Application Date: 2019-08-13
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Publication No.: US20200123160A1Publication Date: 2020-04-23
- Inventor: Jacques Banville , Roger Remillard , Edward H. Ruediger , Daniel H. Deon , Marc Gagnon , Laurence Dube , Julia Guy , Eldon Scott Priestley , Shoshana L. Posy , Brad D. Maxwell , Pancras C. Wong , R. Michael Lawrence , Michael M. Miller
- Applicant: BRISTOL-MYERS SQUIBB COMPANY , UNIVERSITÉ DE MONTRÉAL
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07B59/00 ; A61K51/04 ; A61K31/55 ; A61K31/5386 ; A61K31/435 ; A61K31/553 ; A61K31/541 ; A61K31/5377 ; A61K31/5025 ; A61K31/497 ; A61K31/496 ; A61K31/454 ; A61K31/4439 ; A61K31/433 ; C07D513/04 ; C07D519/00 ; A61K45/06

Abstract:
The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
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