An assembly engine is configured to generate, based on a computer-aided design (CAD) assembly, a set of motion commands that causes the robot to manufacture a physical assembly corresponding to the CAD assembly. The assembly engine analyzes the CAD assembly to determine an assembly sequence for various physical components to be included in the physical assembly. The assembly sequence indicates the order in which each physical component should be incorporated into the physical assembly and how those physical components should be physically coupled together. The assembly engine further analyzes the CAD assembly to determine different component paths that each physical component should follow when being incorporated into the physical assembly. Based on the assembly sequence and the component paths, the assembly engine generates a set of motion commands that the robot executes to assemble the physical components into the physical assembly.