- 专利标题: METHODS AND COMPOSITIONS FOR MODULATING CYTOTOXIC LYMPHOCYTE ACTIVITY
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申请号: US16630887申请日: 2018-07-13
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公开(公告)号: US20200149009A1公开(公告)日: 2020-05-14
- 发明人: Aviv Regev , Ana C. Anderson , Vijay K. Kuchroo , Sema Kurtulus , Asaf Madi
- 申请人: The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
- 国际申请: PCT/US2018/042069 WO 20180713
- 主分类号: C12N5/0783
- IPC分类号: C12N5/0783 ; C07K14/705 ; G01N33/569 ; G01N33/574 ; A61K35/17
摘要:
The subject matter disclosed herein is generally directed to novel CD8+ tumor infiltrating lymphocyte (TIL) subtypes associated with response to immunotherapy treatment. Specifically, the subtypes are associated with checkpoint blockade therapy. Moreover, the subject matter disclosed herein is generally directed to methods and compositions for use of the subtypes. Also, disclosed herein are gene signatures and markers associated with the subtypes and use of said signatures and markers. Further disclosed are therapeutic methods of using said gene signatures and immune cell subtypes. Further disclosed are pharmaceutical compositions comprising populations of CD8+ TILs enriched for a specific subtype.