An internal combustion engine includes low and high pressure turbochargers connected in series. An engine cylinder has an intake valve that fluidly connects a main chamber of the engine cylinder with an outlet of the high pressure compressor through an intake passage. An exhaust gas recirculation passage is fluidly interconnected between exhaust and intake conduits. A pre-chamber encloses a spark plug and is fluidly open with the main chamber of the engine cylinder. A first fluid path extends from the intake passage directly to the pre-chamber, and a second fluid path extends from the intermediate passage directly to the pre-chamber.