Methods, sorbent cartridges and cleaning devices are disclosed for refurbishing sorbent materials. In one implementation among multiple implementations, a medical fluid delivery method includes: providing a sorbent cartridge including H+ZP within a casing for a treatment; and after the treatment, refurbishing the H+ZP while maintained within the casing via (i) regenerating the non-disinfected H+ZP by flowing an acid solution through the casing, (ii) rinsing the regenerated H+ZP while maintained within the casing, (iii) disinfecting the regenerated and rinsed H+ZP by flowing a disinfecting agent through the casing, and (iv) rinsing the regenerated and disinfected H+ZP while maintained within the casing. Multiple batch sorbent refubishing implementations are also disclosed.