An optical signal noise reduction circuit, an optical signal noise reduction method and a display panel are provided in the present disclosure. The optical signal noise reduction circuit includes a reference line, a comparison detection circuitry and a photoelectric signal read line. An electric signal on the photoelectric signal read line includes a noise electric signal and a photoelectric signal. The reference line is configured to sense the noise electric signal on the photoelectric signal read line, to generate a corresponding second electric signal. The comparison detection circuitry is connected to the reference line and the photoelectric signal read line, and configured to acquire the photoelectric signal in accordance with the electric signal on the photoelectric signal read line and the electric signal on the reference line.