Disclosed herein are a method and apparatus for measuring video quality based on a perceptually sensitive region. The quality of video may be measured based on a perceptually sensitive region and a change in the perceptually sensitive region. The perceptually sensitive region includes a spatial perceptually sensitive region, a temporal perceptually sensitive region, and a spatio-temporal perceptually sensitive region. Perceptual weights are applied to a detected perceptually sensitive region and a change in the detected perceptually sensitive region. Distortion is calculated based on the perceptually sensitive region and the change in the perceptually sensitive region, and a result of quality measurement for a video is generated based on the calculated distortion.