Methods of acquiring cellular and tissue vibrational patterning to identify signatures capable to induce pluripotency and commitment towards defined lineages, as well as survival under hostile conditions (i.e. oxidative stress) in both human adult stem cells and human adult somatic cells are described. Specifically, the invention relates to the delivery of such signatures to human adult stem cells or human adult somatic cells to induce specific differentiation processes and promote survival to hostile environmental conditions. Further methods are described of targeting tissue resident in vivo to retrieve their ability to sustain self-healing process, therefore affording a Regenerative Medicine executed without the needs for (stem) cell or tissue transplantation.