The present disclosure pertains to a system for facilitating configuration modifications for a patient interface computer system based on a patient-specific risk alert model. In some embodiments, the system obtains (i) lifestyle information associated with a patient, (ii) disease information associated with the patient, and (iii) one or more physiological measurements of the patient. The system monitors the patient for one or more threshold levels of exacerbation based on a risk alert model, the lifestyle information, the disease information, and the one or more physiological measurements. The system causes a configuration of the patient interface computer system to be modified based on the monitoring for the one or more threshold levels of exacerbation.