- 专利标题: COMPOUNDS FOR REDUCING THE VISCOSITY OF BIOLOGICAL FORMULATIONS
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申请号: US16644107申请日: 2018-08-31
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公开(公告)号: US20200206350A1公开(公告)日: 2020-07-02
- 发明人: Lin Chu , Nathalie Y. Toussaint , Dong Xiao , Petr Vachal , Ramesh S. Kashi , Annette Bak
- 申请人: Merck Sharp & Dohme Corp.
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 国际申请: PCT/US18/48995 WO 20180831
- 主分类号: A61K47/22
- IPC分类号: A61K47/22 ; C07K16/28 ; A61K47/26 ; C07D233/64 ; C07C279/14 ; C07C235/12 ; C07C229/36 ; A61K47/18
摘要:
The present invention relates to pegylated amino acid compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3A, R3B and n are as defined herein. The present invention also relates to compositions which comprise a pegylated amino acid compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, in combination with a high concentration of an active biological ingredient (ABI). In embodiments of the invention, the ABI is an anti-PD-1 antibody or antigen binding fragment thereof that specifically binds human programmed death receptor 1 (PD-1). The invention further relates to methods for lowering the viscosity of an aqueous solution of a pharmaceutical composition comprising adding a compound of the invention to the solution. The invention also provides methods for treating a pathological disease or condition, such as cancer, by administering to a subject in need of such treatment a therapeutically effective amount of a pharmaceutical composition of the invention.
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