- 专利标题： 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
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申请号： US16621959申请日： 2018-06-22
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公开(公告)号： US20200207758A1公开(公告)日： 2020-07-02
- 发明人: John J. ACTON, III , Jianming BAO , Qiaolin DENG , Melissa EGBERTSON , Ronald FERGUSON, II , Xiaolei GAO , Scott Timothy HARRISON , Sandra L. KNOWLES , Chunsing LI , Michael Man-Chu LO , Robert D. MAZZOLA, Jr. , Zhaoyang MENG , Meng NA , Michael T. RUDD , Oleg SELYUTIN , David M. TELLERS , Ling TONG , Fengqi ZHANG
- 申请人： John J. ACTON, III , Jianming BAO , Qiaolin DENG , Melissa EGBERTSON , Ronald FERGUSON, II , Xiaolei GAO , Scott Timothy HARRISON , Sandra L. KNOWLES , Chunsing LI , Michael Man-Chu LO , Robert D. MAZZOLA, Jr. , Zhaoyang MENG , Meng NA , Michael T. RUDD , Oleg SELYUTIN , David M. TELLERS , Ling TONG , Fengqi ZHANG
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@6a7193e6
- 国际申请： PCT/US18/38888 WO 20180622
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D401/14 ; C07D401/04 ; C07D413/14 ; C07D405/14 ; C07D491/048 ; C07D498/04
摘要：
The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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