Disclosed are a method and a device for transmitting and receiving a signal, the method including: identifying a downlink signal-only transmission section in which a first electronic device transmits a downlink signal to a second electronic device, and transmitting the signal in the downlink signal-only transmission section; detecting at least one symbol that has a power value relatively higher than a predetermined threshold value; estimating, on the basis of the detected at least one symbol, an interference channel in which a self-interference signal occurs; detecting the self-interference signal; and identifying an FDX transmission section in which an uplink signal is received from the second electronic device and the downlink signal is transmitted simultaneously, and processing transmission of the downlink signal and reception of the uplink signal in the FDX transmission section, wherein the reception of the uplink signal is processed by removing the self-interference signal occurring in the interference channel.