- 专利标题： BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING
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申请号： US15750708申请日： 2016-08-03
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公开(公告)号： US20200215108A1公开(公告)日： 2020-07-09
- 发明人: Michael C. Jensen
- 申请人： SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE)
- 国际申请： PCT/US2016/045360 WO 20160803
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C07K16/30 ; C07K14/725 ; C07K14/705 ; A61P35/00
摘要：
Disclosed herein are methods of engineering a bi-specific T-cell expressing chimeric antigen receptors for promoting the in vivo expansion and activation of an effector cell and a second chimeric antigen receptor or TcR specific for a ligand on a tumor. Methods of administering to subjects in need, bi-specific chimeric antigen receptor bearing cells are also provided.
公开/授权文献
- US11458167B2 Bispecific CAR T-cells for solid tumor targeting 公开/授权日：2022-10-04
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