A pressure reference resetting structure of an inflatable mattress, the inflatable mattress contains a valve connected with an end of the inflatable mattress, an inflatable air pump connected with the valve, and the valve being connected with a pressure detection pipe which is coupled with a pressure sensing element. The valve includes an air orifice communicated with the pressure detection pipe so that the pressure sensing element detects a pressure of an external environment via the pressure detection pipe and the air orifice, and a reference pressure of the inflatable mattress is reset to inflate the inflatable mattress based on the reference pressure.