Provided are systems and methods for photorealistic real-time portrait animation. An example method includes receiving a scenario video with at least one input frame. The input frame includes a first face. The method further includes receiving a target image with a second face. The method further includes determining, based on the at least one input frame and the target image, two-dimensional (2D) deformations, wherein the 2D deformations, when applied to the second face, modify the second face to imitate at least a facial expression and a head orientation of the first face. The method further includes applying, by the computing device, the 2D deformations to the target image to obtain at least one output frame of an output video.