- 专利标题: 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
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申请号: US16303539申请日: 2017-05-23
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公开(公告)号: US20200237757A1公开(公告)日: 2020-07-30
- 发明人: Norbert SCHMEES , Ilona GUTCHER , Horst IRLBACHER , Benjamin BADER , Na ZHAO , Michael PLATTEN , Ulrike ROEHN , Ludwig ZORN , Lars ROESE , Detlef STOECKIGT
- 申请人: BAYER PHARMA AKTIENGESELLSCHAFT , DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ)
- 申请人地址: DE Berlin DE Heidelberg
- 专利权人: BAYER PHARMA AKTIENGESELLSCHAFT,DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ)
- 当前专利权人: BAYER PHARMA AKTIENGESELLSCHAFT,DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ)
- 当前专利权人地址: DE Berlin DE Heidelberg
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@718e0158 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@23b444a8
- 国际申请: PCT/EP2017/062355 WO 20170523
- 主分类号: A61K31/501
- IPC分类号: A61K31/501 ; A61K45/06 ; C07D237/24 ; C07D405/12 ; C07D403/12 ; A61K31/50 ; A61P35/00
摘要:
The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
公开/授权文献
- US11040035B2 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides 公开/授权日:2021-06-22
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