- 专利标题: USE OF AMINE CARBOXYBORANES AS THERAPEUTIC DELIVERY OF CARBON MONOXIDE AND AS GENERAL DRUG DELIVERY SYSTEM IN THE PRESENCE OF REACTIVE OXYGEN SPECIES
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申请号: US16863715申请日: 2020-04-30
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公开(公告)号: US20200255455A1公开(公告)日: 2020-08-13
- 发明人: Nin N. Dingra , Theppawut Israsena Na Ayudhya
- 申请人: University of Alaska Anchorage , Florida Southwestern State College , The Research Foundation for the State University of New York
- 主分类号: C07F5/02
- IPC分类号: C07F5/02 ; A61K31/69 ; A61P43/00
摘要:
Disclosed is a method of delivering therapeutic carbon monoxide to the cells and tissues of a patient which comprises administering thereto a compound of the formula XBY1Y2C(O)V (I) or pharmaceutically acceptable salts thereof. In addition, disclosed is a method of delivering a drug to a diseased cell or tissue by administering a compound of formula I either wherein at least one of X is a drug containing an amino group or V is a drug containing an amino group or hydroxyl group less a hydrogen on the amino or hydroxyl group. Further disclosed are novel compounds of Formula I.
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