The present technology relates to a focus detection device and method and a program by which an accurate image shift amount can be detected. A calculation unit performs calculation based on learning on the basis of a received light amount distribution of an A pixel group having a first property for phase difference detection and a received light amount distribution of a B pixel group having a second property different from the first property and outputs defocus amount related information relating to a defocus amount. The present technology can be applied to an imaging apparatus that performs focus detection by a phase difference detection method.